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Workshop

 

Nächster Workshoptermin in Berlin:

16. November / 17. November 2007

 

 

Nächster Workshoptermin in Rottenburg:

30.November / 1.Dezember 2007

 

 

 

weitere Informationen erhalten Sie unter

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AESCULAP AKADEMIE GmbH

Manuela Roth

Am Aesculap-Platz

78532 Tuttlingen

tel.: +49 (0) 7461 95-2186

fax: +49 (0) 7461 95-2050

manuela.roth@aesculap-akademie.de

 

   
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Literatur

 

Veröffentlichungen unter Beteiligung von Mitarbeitern unserer Arbeitsgruppe:

 

Stoop R, Albrecht D, Gaissmaier C, Fritz J, Felka T, Rudert M, Aicher WK. Comparing marker gene expression in chondrocytes

from patients receiving autologous chondrocyte transplantation (ACT) versus osteoarthritis patients.

Arthritis Research & Therapy 2007; [in press].

 

Spahn G, Plettenberg H, Nagel H, Kahl E, Klinger HM, Muckley T, Gunther M, Hofmann GO, 
Mollenhauer JA. Evaluation of cartilage defects with near-infrared spectroscopy (NIR): An ex vivo study. Med Eng Phys 2007; 
[Epub ahead of print].
 

Bühring HJ, Battula VL, Treml S, Schewe B, Kanz L, Vogel W. Novel markers for the prospective isolation of human MSC. Ann N Y Acad Sci 2007; [Epub ahead of print].

 

Ochs BG, Müller-Horvat C, Rolauffs B, Fritz J, Weise K, Schewe B. [Treatment of osteochondritis dissecans of the knee: one-step procedure with bone grafting and matrix-supported autologous chondrocyte transplantation]. Z Orthop Unfall 2007; 145: 146-151.

 

Battula VL, Bareiss PM, Treml S, Conrad S, Albert I, Hojak S, Abele H, Schewe B, Just L, Skutella T, Bühring HJ. Human placenta and bone marrow derived MSC cultured in serum-free, b-FGF-containing medium express cell surface frizzled-9 and SSEA-4 and give rise to multilineage differentiation. Differentiation 2007; 75: 279-291.

 

Mollenhauer JA. The notochord in the mammalian adult: A paradox. Arthritis Rheum 2006; 54: 3728-3729.
 

Gaissmaier C, Fritz J, Schewe B, Albrecht D, Weise K, Stoop R, Fink U, Giordano N, Ashammakhi N, Aicher WK. Development of NOVOCART® 3D, a novel system of scaffold augmented transplantation of autologous chondrocytes. In: Basic Science, Clinical Repair and Reconstruction of Articular Cartilage Defects: Current Status and Prospects (Vol. 1). Zanasi S, Brittberg M, Marcacci M (Ed). Timeo Editore 2006; 573-585.

 

Fichter M, Körner U, Schömburg J, Jennings L, Cole AA, Mollenhauer JA. Collagen degradation products modulate matrix metalloproteinase expression in cultured articular chondrocytes. J Orthop Res 2006, 24: 63-70.

 
Aurich M, Eger W, Rolauffs B, Margulis A, Kuettner KE, Mollenhauer JA, Cole AA. [Ankle 
chondrocytes are more resistant to Interleukin-1 than chondrocytes derived from the knee]. Orthopäde 2006; 35: 784-790.
 

Gaissmaier C, Fritz J, Schewe B, Weise K, Mollenhauer JA, Aicher WK. Cartilage Defects: Epidemiology and Natural History. Osteosynthesis and Trauma Care 2006; 14: 188-194.

 

Aurich M, Anders J, Trommer T, Liesaus E, Seifert M, Schomburg J, Rolauffs B, Wagner A, 
Mollenhauer JA. Histological and cell biological characterization of dissected cartilage fragments in human osteochondritis dissecans 
of the femoral condyle. Arch Orthop Trauma Surg 2006; 126: 606-614.

 

Fritz J, Gaissmaier C, Schewe B, Weise K. [Cartilage repair in the knee joint]. Unfallchirurg 2006; 109: 563-574.

 

Schewe B, Fritz J, Gaissmaier C, Weise K. [Cartilage cell transplant: surgical technique with matrix-associated chondrocytes]. Unfallchirurg 2006; 109: 577-582.

 

Gaissmaier C, Fritz J. [Origin and epidemiology of articular cartilage defects in the knee]. Arthritis & Rheuma 2005; 25: 293-298.

 

Mollenhauer JA. Biologica – Knorpelersatz und autologe Chondrocytentransplantation. M&K Orthopädie 2005; 1: 34-35.

 

Sachse A, Wagner A, Keller M, Wagner O, Wetzel WD, Layher F, Venbrocks RA, Hortschansky P, Pietraszczyk M, Wiederanders B, Hempel HJ, Bossert J, Horn J, Schmuck K, Mollenhauer JA. Osteointegration of hydroxyapatite-titanium implants coated with nonglycosylated recombinant human bone morphogenetic protein-2 (BMP-2) in aged sheep. Bone 2005; 37: 699-710.

 

Aurich M, Squires GR, Reiner A, Mollenhauer JA, Kuettner KE, Poole AR, Cole AA. Differential matrix degradation and turnover in early cartilage lesions of human knee and ankle joints. Arthritis Rheum 2005; 52: 112-119.

 

Kluba T, Niemeyer T, Gaissmaier C, Gründer T. Human annulus fibrosus and nucleus pulposus cells of the intervertebral disc: Effect of degeneration and culture system on cell phenotype. Spine Journal 2005; 30: 2743-2748.

 

Roth A, Mollenhauer JA, Wagner A, Fuhrmann R, Straub A, Venbrocks RA, Petrow P, Bräuer R, Schubert H, Ozegowski J, Peschel G, Müller PJ, Kinne RW. Intra-articular injections of high-molecular-weight hyaluronic acid have biphasic effects on joint inflammation and destruction in rat antigen-induced arthritis. Arthritis Research & Therapy 2005; 7: 677-686.

 

Fritz J, Gaissmaier C, Schewe B, Weise K. [Significance and technique of autologous chondrocyte transplantation]. Zentralblatt Chirurgie 2005; 130: 327-332.

 

Li J, Williams JM, Zhong Z, Kuettner KE, Aurich M, Mollenhauer JA, Muehleman C. Reliability of diffraction enhanced imaging for assessment of cartilage lesions, ex vivo. Osteoarthritis & Cartilage 2005; 13: 187-197.

 

Fritz J, Gaissmaier C, Schewe B, Krackhardt T, Weise K. [Status Quo in Articular Cartilage Surgery an Overview]. Akt Traumatol 2005; 35: 260-266.

 

Gaissmaier C, Fritz J, Schewe B, Albrecht D, Weise K. Development of a novel collagene-based biphasic carrier for matrix-assisted transplantation of autologous chondrocytes. Akt Traumatol 2005; 35: 267-273.

 

Gaissmaier C, Fritz J, Krackhardt T, Flesch I, Aicher WK, Ashammakhi N. Effect of human platelet supernatant on proliferation and matrix synthesis of human articular chondrocytes in monolayer (2D) and three-dimensional (3D) alginate cultures. Biomaterials 2005; 26: 1953-1960.

 

Gründer T, Gaissmaier C, Fritz J, Stoop R, Hortschansky P, Mollenhauer JA, Aicher WK. Bone morphogenetic protein (BMP)-2 enhances the expression of type II collagen and aggrecan in chondrocytes embedded in alginate beads. Osteoarthritis & Cartilage 2004; 12: 559-567.

 

Muehleman C, Majumdar S, Sema Issever A, Arfelli F, Menk RH, Rigon L, Heitner G, Reime B, Metge J, Wagner A, Kuettner K, Mollenhauer JA. X-ray detection of structural orientation in human articular cartilage. Osteoarthritis & Cartilage 2004, 12: 97-105.

 

Aicher WK, Gaissmaier C, Fritz J. Quality assurance of autologous chondrocyte transplantation (AC). In: Hendrich C, Nöth U, Eulert J (Ed). Cartilage surgery and future perspectives. Springer-Verlag Heidelberg 2003; 123-129.

 

Aicher WK, Fritz J, Kötter I. Bioartifizieller Gewebeersatz – Tissue Engineering. Molekularmedizinische Grundlagen von rheumatischen Erkrankungen. In Ganten/Ruckpaul (Hrsg.). Springer-Verlag Heidelberg 2003; 79-103.

 

Aicher WK, Fritz J, Steinbach K, Krackhardt T, Weise K, Gaissmaier C. Molekularbiologische und klinische Qualitätssicherung der autologen Chondrozytentransplantation (ACT). Orthopädische Praxis 2003; 39: 171-173.

 

Aicher WK, Gaissmaier C. Ausblicke und Zukunftsperspektiven für die Autologe Chondrocytentransplantation (ACT). In: Fritz J, Aicher WK, Eichhorn HJ (Hrsg). Praxisleitfaden der Knorpelreparatur. Springer-Verlag Heidelberg 2003; 143-146.

 

Steinbach K. Von der Biopsie zur Zellkultur. Die ACT aus der Sicht eines Arzneimittelherstellers. In: Fritz J, Aicher WK, Eichhorn HJ (Hrsg). Praxisleitfaden der Knorpelreparatur. Springer-Verlag Heidelberg 2003; 11-23.

 

Aicher WK, Gaissmaier C. Qualitätssicherung in der therapeutischen Zellkultur – zell- und molekularbiologische Aspekte. In: Fritz J, Aicher WK, Eichhorn HJ (Hrsg). Praxisleitfaden der Knorpelreparatur. Springer-Verlag Heidelberg 2003; 25-47.

 

Fritz J. Technik der autologen Chondrocytentransplantation. In: Fritz J, Aicher WK, Eichhorn HJ (Hrsg). Praxisleitfaden der Knorpelreparatur. Springer-Verlag Heidelberg 2003; 85-95.

 

Mollenhauer JA, Aurich M, Muehleman C, Khelashvilli G, Irving TC. X-ray diffraction of the molecular substructure of human articular cartilage. Connect Tissue Res 2003; 44: 201-207.

 

Fritz J. Differentialindikationen zu unterschiedlichen biologischen Rekonstruktionsverfahren. In: Fritz J, Aicher WK, Eichhorn HJ (Hrsg). Praxisleitfaden der Knorpelreparatur. Springer-Verlag Heidelberg 2003; 97-109.

 

Lucic D, Mollenhauer JA, Kilpatrick KE, Cole AA. N-telopeptide of type II collagen interacts with annexin V on human chondrocytes. Connect Tissue Res 2003; 44: 225-239.

 

Gaissmaier C, Fritz J, Mollenhauer JA, Schneider U, Marlovits S, Anders J, Schewe B, Weise, Kuno. [Outcome of clinically overt cartilage injuries without and with biological reconstruction]. Dtsch Ärztebl 100: A 2448 - 2453 [Heft 38], 2003.

 

Gaissmaier C, Fritz J, Benz K et al. Biomaterialien für die Transplantation chondrogener Zellen zur biologischen Rekonstruktion artikulärer Knorpeldefekte. SFA-Arthroskopie aktuell 2003; 16: 4-14.

 

Eger W, Schumacher BL, Mollenhauer JA, Kuettner KE, Cole AA. Human knee and ankle cartilage explants: catabolic differences. J Orthop Res 2002; 20: 526-534.

 

Mollenhauer JA, Aurich M., Dix WR, Freudenberger J, Lohmann M, Metge J, Reime B, Sachse A, Schmuck K, Sieber N, Wagner A. Monitoring of bone and cartilage pathologies by diffraction-enhanced imaging (DEI). Hasylab Annual Report 2002 http://www-hasylab.desy.de/science/annual_reports/ 2002_report/

 

Jennings L, Haemmerle H, King KB, Wu L, Cs-Szabo G, Mollenhauer JA. Metabolic effects of collagen fragments on the matrix metabolism in bovine and human chondrocytes. Connect Tissue Res 2001; 42: 71-86.

 

Weise K, Krackhardt T, Gaissmaier C. Die operative Behandlung von Gelenkknorpeldefekten unter besonderer Berücksichtigung der autologen Knorpelzelltransplantation: Grundlagen - Ergebnisse - Ausblick. OP-Journal 2000; 16: 150-159,.

 

Weise K, Fritz J, Hörnlein RS, Krackhardt T, Gaissmaier C. Die autologe Chondrocytentransplantation. Grundlagen, aktueller Stand und Ausblick. Deutsche Gesellschaft für Unfallchirurgie (DGU), Mitteilungen und Nachrichten 1999; 39: 28-38.

 

Eingartner C, Coerper S, Fritz J, Gaissmaier C, Koveker G, Weise K. Growth factors in distraction osteogenesis. Immuno-histological pattern of TGF-beta1 and IGF-I in human callus induced by distraction osteogenesis. Int Orthop 1999; 23: 253-259.

 

Gaissmaier C, Fritz J, Müller JE, Krackhardt T, Rether JR, Höntzsch D, Weise K. Autologe Knorpelzelltransplantation Indikation und Technik. Akt Traumatol 1998; 28: 245-250.

 

Sell S, Gaissmaier C, Fritz J, Herr G, Esenwein S, Kusswetter W, Volkmann R, Wittkowski KM, Rodemann HP. Different behavior of human osteoblast-like cells isolated from normal and heterotopic bone In vitro. Calcif Tissue Int 1998; 62: 51-59.

 

 

 

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Empfehlungen der Fachgesellschaften:

Behrens P, Bruns J, Erggelet CH, Esenwein S, Gaissmaier C, Krackhardt T, Lohnert J, Marlovits S, Meenen NM, Mollenhauer J, Nehrer S, Niethardt FU, Noth U, Perka C, Richter W, Schäfer D, Schneider U, Steinwachs M, Weise K. Recommendations for indication and application of ACT of the joined advisory board of the German Societies for Traumatology (DGU) and Orthopaedic Surgery (DGOOC). Z Orthop Ihre Grenzgeb 142: 529-39, 2004.

P. Behrens, J. Bruns, Ch. Erggelet, S. Esenwein, Ch. Gaissmaier, Ch. Gekle, T. Krackhardt, S. Marlovits, J. Mollenhauer, F.U. Niethardt, C. Perka, K. Ruhnau, U. Schneider, M. Steinwachs, K. Weise. AG "ACT und Tissue engineering"" unter Schirmherrschafte der DGU und DGOOC.  DGU - Mitteilungen und Nachrichten 45/2002.

 

 

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Veröffentlichungen anderer Autoren:

Knutsen G et al. Autologous chondrocyte implantation compared with microfracture in the knee - a randomized trial.

J Bone Joint Surg Am 86: 455-464, 2004.

 

Bentley G et al. A prospective randomised comparison of autologous chondrocyte implantation versus mosaicplasty for osteochondral defects in the knee. J Bone Joint Surg Br 85:.223-230, 2003.

 

Peterson L et al. Autologous chondrocyte transplantation. Biomechanics and long-term durability. AM J Sports Med 30: 2-12, 2002.

 

Peterson L, Articular cartilage transplantation 13 years experience. J Bone Joint Surg Br 25: 1109-1115, 2002.

 

Roberts S et al. Matrix turnover in human cartilage repair tissue in autologous chondrocyte implantation. Arthritis Rheum 44: 2586-2598, 2001.

Dell'Accio F et al. Molecular markers predictive of the capacity of expanded human articular chondrocytes to form stable cartilage in vivo. Arthritis Rheum 44: 1608-1619, 2001.

Peterson L et al. Two- to 9-year outcome after autologous chondrocyte transplantation of the knee. Clin Orthop 374: 212-234, 2000.

Richardson et al. Repair of human articular cartilage after implantation of autologous chondrocytes. J Bone Joint Surg Br 81: 1064-1068, 1999.

Brittberg M et al. Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. N Engl J Med 331: 889-895, 1994.

 

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